One of the biggest issues in the supplement industry is the use of clinical or efficacious doses. This issue revolves around a large majority of companies not basing their product on the correct dose that has been verified and proven in research.
While people often overlook the amount of each specific ingredient, just browsing the actual ingredient name is a common mistake. Logically, the actual amount of that ingredient is just as, if not more important than the included ingredients.
This article breaks down the key concepts, importance and provides an overview of clinical dosing.
Clinical Dosing 101 - What You Need to Know…
Clinical dosing describes a rare yet important aspect of supplement creation. In short, clinical dosing is when a supplement company bases their ingredient and supplement creation on the research proven doses. While this sounds like a no-brainer, more often than not companies will use the key, backed ingredients but they FAIL to use a proven dose to provide benefit.
As I’ve wrote several times, if they do use certain ingredients at the wrong dose for the most part its just a totally wasted ingredient (which costs you money!). This is because your body and the receptors within your cells need a certain amount (e.g. 5 grams) to raise the bodies levels and signal the cells to respond. When the ingredient doesn’t meet this proven amount, it fails to signal the body or elicit the desired performance effect you are after.
In short, if your supplement company doesn’t use the correct dose, 95% of the time that ingredient is just a waste of money and acts as a sales based “filler”.
This is established after an extremely intensive, complex and costly research process. Usually, it will take several years for the scientific researchers to really establish the proven dose, with several labs testing the given ingredient around the world using different methods, study designs and protocols.
While many people may assume that its just one simple study where someone drinks a few different doses this couldn’t be further from the case. In science, the research must be overwhelmingly supportive and well designed. For scientists to provide a given or recommended amount it will usually require years of research. For example, some of the core ingredients such as creatine, beta alanine and caffeine have several hundred studies supporting their use and the correct dose.
How Scientists Establish the Research Proven Dose
From the ground up, the process usually starts with some dosing only studies. In humans or animals, this may involve the ingredient being provided at several different doses, e.g. 1, 2, 3, 4, 5, 10g and then complex tracers and cellular methods will test how these different dosages effect the body and target cells.
After these sort of baseline studies are conducted, cellular research may follow. This is more chemical and molecular research in live cells with scientists studying the ingredients interacting at a fundamental and most basic level. For these types of studies, think about some cells being examined under a microscope.
After the baseline dosing studies have been conducted by numerous different laboratories it usually moves onto the “benefits” studies. As the name suggests, they now test the proven amounts and monitor what benefits the supplement actually provides. This is obviously just as important, even if a supplement is having an effect within the body, if this doesn’t produce a physical benefit such as better energy, fat loss, strength, muscle growth etc. then it really has no relevance.
The final stage is to now test different training protocols and see how the ingredient provides benefits in varied situations. For example, some initial research may show that a certain ingredient improves weight training performance, however, “weight training performance” is extremely broad. Following this, years of research will continue to test different variables, such as rep range, rest times, exercise selection (compound vs isolation), gender, training level (beginner vs advanced) and more.
Clinical Dosing is Fundamental for any Supplement Company
As you can see, this extremely timely, costly and complex process is vitally important. It provides actual evidence and support for a supplement product creation and ultimately, provides you a true reason to spend money.
Far too often, supplement companies will throw in random ingredients that have not gone through this process, or worse still, they will throw in a supplement that HAS been proven but they still choose to pick a wrong dose.
Why would they do this? It’s a great question and from a business and ethical standpoint it makes little sense. However, from a pure cost and sales perspective it allows the supplement company to save money (using less of the ingredient) but still advertising that it’s “included”, which to 99% of customers is enough for them to buy the product.
As you now know, unless its included at the CORRECT dose, it’s pretty much pointless.
Always check the label and actually read the ingredient dosing, make sure it mimics the research and is actually the correct clinical dose, like all the KAGED MUSCLE products.
Once you start looking, you will quickly see 95% of products are off the mark. For more information on this and how to check what is actually support by research read this article.Link to the “How to Read Research article”