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GLUTAMINE

GLUTAMINE
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FERMACEUTICAL GRADE
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FERMACEUTICALTM GRADE

WHY
GLUTAMINE?

Glutamine is the most abundant amino acid in the human body. Though not considered an “essential” amino acid, it is without question a “conditional” amino acid. There are 3 unique yet interwoven factors that can dramatically increase demand for glutamine within the human body; these include enhanced muscle exertion and recovery, immune support, and gastrointestinal health.


 

MUSCLE
HEALTH

Stress is the ultimate enemy of the human mind and body. Glutamine is no exception to the ravages of stress. The stress hormone cortisol is “catabolic” leading to breaking down the body and tissues. Whereas, the goal is an “anabolic” building mode. No matter how chill and no worries attitude you may have. Living in the modern helter-skelter world wears down even the most easy-going person. Remember stress is not just a mental state of mind, lack of sleep, long work hours or a hostile work environment; relationship issues, a cold or flu and even food allergens/intolerances are all perceived as enemies of the “state of thriving” not just surviving.

IMMUNE
HEALTH

Working yourself to sickness does happen, whether it’s overtraining while being insufficiently fueled with inadequate nutrients and rest or life stress.

When an individual gets seriously ill, they can experience a drop in plasma glutamine levels of up to 58% during critical illness and these levels have been shown to remain low upwards of 3 weeks. (1) So needless to say, if you have been fighting a cold, your muscles and performance can pay.

INTESTINAL
HEALTH

When working out, glutamine is rapidly released from muscle stores to sustain the gastrointestinal tract, allowing absorptive cells lining the intestine to perform as intended. (1)

Consuming and absorbing performance optimizing nutrients is like a relay race; if you can’t pass the baton successfully, the race is over before you cross the finish line. If you suffer from a lack luster GI tract when it comes to performance, it will become a rate limiting factor for you reaching your full potential. Why? Because you will be under-fueled relative to your strategic efforts to peak your potential with a great diet and supplementation routine.

BENEFITS OF 
KAGED MUSCLE L-GLUTAMINE

  • FERMENTATION DERIVED VS. SYNTHETIC
  • GRAS APPROVED
  • ONLY GLUTAMINE MANUFACTURED IN THE USA
DARE TO COMPARE
OUR GLUTAMINE TO THE COMPETITION


Glutamine-Compare ours to the competition

DID YOU KNOW?
Most Glutamine on the market today is made from duck feathers and human hair
NOT OURS!

WHY FERMENTED L-GLUTAMINE 
IS THE BEST

Most glutamine supplements you see in the market are from shellfish, human hair, and bird feathers which are not the cleanest source for L-Glutamine.

Fermented L-Glutamine is the purest L-Glutamine you can buy. It's all vegan, non-GMO, free from impurities, heavy metals, and hidden micro toxins.

GELATIN VS
VEGETABLE CAPSULES

What are Gelatin capsules made from?

  1. Skin
  2. Bones
  3. Connective Tissue (cattle, chicken, pigs, fish)
  4. All of the above

Gelatin is a mixture of peptides and proteins produced by partial hydrolysis of collagen extracted from the skin, bones, and connective tissues of animals such as domesticated cattle, chicken, pigs, and fish.

It is hard to believe what types of inferior and downright disgusting ingredients manufacturers sneak into items such as capsules. You are trying to get healthy and fit by taking supplements and instead you are consuming preservatives and animal products that you don’t want in your body!

When buying ANY supplement in capsule format be sure to look at the other ingredients section on the supplement facts panel to see if the capsules are made from gelatin or vegetable sources.

Other Ingredients: 
Gelatin, Microcrystalline, Cellulose, Magnesium, Stearate.

ALL Kaged Muscle products are formulated with Non-GMO, Gluten Free, 100% plant-derived capsules and DO NOT contain Gelatin.

JUST SAY NO
TO GELATIN!

*It is important for consumers to note that in purchasing a glutamine supplement, quality should be considered over price. Cheaply priced glutamine is generally indicative of low-quality raw materials used in the manufacturing process. With MICROPURE™ Glutamine by Kaged Muscle, you can be assured that you are getting the highest quality free-form glutamine available.

BETTER
TOGETHER

Combining Kaged Muscle’s BCAA, Glutamine, and Hydra-Charge is the perfect combination to help you achieve your fitness goals.

 

 

 

  1. Wischmeyer PE. Clinical applications of L-glutamine: Past, present, and future. Nutr Clin Prac. 2003;18(5):377-385.
  2. Bowtell JL, Gelly K, Jackman ML, Patel A, Simeoni M, Rennie MJ. Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise. J Appl Physiol. 1999;86:1770-7.
  3. Caris AV et al.Carbohydrate and glutamine supplementation modulates the Th1/Th2 balance after exercise performed at a simulated altitude of 4500 m. Nutrition. 2014 Nov-Dec;30(11-12):1331-6.
  4. Laviano A, et al. Eur J Clin Nutr. 2014 Sep 17
  5. Jeukendrup AE, Gleeson M. Sports nutrition: an introduction to energy production and performance. Champaign (IL): Human Kinetics; 2004.
  6. Silva AC et al. Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. J Pediatr Gastroenterol Nutr. 1998;26:513–9
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
KM-GLUP-500

Other Ingredients: None

Glutamine is the most abundant amino acid in the human body. Though not considered an “essential” amino acid, it is without question a “conditional” amino acid. There are three unique yet interwoven factors that can dramatically increase demand for glutamine within the human body; these include enhanced muscle exertion and recovery, immune support and gastrointestinal health. Clinically, these key wellness factors are what I call the “big three glutamine demands”, as you can see in the figure below.

Glutamine is vitally important for sustaining overall health and your body generally makes a sufficient amount for “ status quo” type days. However, when your expectations and demands for your body go up, so does the need for more glutamine. This is particularly the case when you are cranking up your efforts during relatively heavy, intense, and sustained exercise routines. When looking to augment your glutamine levels you want to make sure that you seek purity, guaranteed pharmaceutical grade, and my preference is a vegetable fermented source. Kaged Muscle MICROPURE is what I have recommended for top athlete patients of mine such as Kris Gethin.

To avoid risking hitting the proverbial wall when it comes to sustained gains, my high intensity athletic patients hit their glutamine supplementation routine. What I have discovered over the decades is that athletes do well the first couple weeks of a new routine or increased intensity, yet without enough fuel they get stuck in the catch 22 of more effort and less measurable gains. Needless to say, this can increase frustration levels as they are putting the time in without max gains. The savvy athlete can fall prey to the temptation of just working out even harder, as many are true competitors in various athletic fields of interest, such as swimmers that hold world records, marathoners and ultra-marathoners, tri-athletes, MMA fighters, bodybuilders, CrossFit devotees, and the list goes on. The key is work out hard, but work out smart by fueling “the machine” through both the humps and valleys of enhanced conditioning.

It comes as no surprise to my patients seeking the extra edge when I share with them that a vast amount of glutamine is stored in their muscles. Other than exercise demands, working out at altitude, infections, chronic stress, surgery, and various health issues can all take away from what would otherwise be sufficient daily levels made by your body.

Intestinal Health

Let’s start our discussion with the ultimate foundation of any health goal, which is the health of your gastrointestinal tract. It has long held that all health and/or disease begins in the gut. It’s a fact that if you don’t have a healthy GI tract you won’t be able to optimally absorb the nutrients that you consume in the form of supplements. I share with my patients this analogy that if an individual suffers from a poor digestive tract, it is like having a hole in a bucket. There are nutrients that pass through the bucket and are lost because they can’t be used as intended.

When working out, glutamine is rapidly released from muscle stores to sustain the gastrointestinal tract, allowing absorptive cells lining the intestine to perform as intended. 1

Consuming and absorbing performance optimizing nutrients is like a relay race; if you can’t pass the baton successfully, the race is over before you cross the finish line. If you suffer from a lackluster GI tract when it comes to performance, it will become a rate limiting factor for you reaching your full potential. Why? Because you will be under-fueled relative to your strategic efforts to peak your potential with a great diet and supplementation routine.

Muscle Health

Stress is the ultimate enemy of the human mind and body. Glutamine is no exception to the ravages of stress. The stress hormone cortisol is “catabolic” leading to breaking down the body and tissues, whereas the goal is an “anabolic” building mode. Living in the modern helter-skelter world wears down even the most easygoing person. Remember that stress is not just a mental state of mind, lack of sleep, long work hours or a hostile work environment; relationship issues, a cold or flu and even food allergens/intolerances are all perceived as enemies of the “state of thriving” not just surviving.

So what does the scientific literature have to say? Let’s take a look at an excerpt from the scientific literature as reported in The Journal of Applied Physiology :

There is some evidence for an effect of glutamine supplements in promoting glycogen synthesis in the first few hours of recovery after exercise: 8 g of glutamine in addition to 61 g of glucose polymer ingested after a glycogen-depleting bout of exercise resulted in a 25% increase in whole body glucose disposal in the h 2 of recovery compared with glucose polymer alone. 2

Immune System Health

Working yourself to sickness does happen, whether it’s overtraining while being insufficiently fueled with inadequate nutrients and rest or life stress. This is actually in part where parental advice of wearing your jacket when it’s cold outside comes from: “Put your jacket on before you go outside because you might catch a cold.” Excess overheating or chilling are physiological stressors to the body.

When an individual gets seriously ill, they can experience a drop in plasma glutamine levels of up to 58% during critical illness and these levels have been shown to remain low upwards of 3 weeks. 1So needless to say, if you have been fighting a cold, your muscles and performance can pay. Likewise, since glutamine is a conditional amino acid, I clinically see many of my patients that are sticking to a strict diet and supplementation routine have increased susceptibility to illness.

You will be amazed at what the research has to say:

Goal of the study:

“The aim of this study was to evaluate the effect of carbohydrate or glutamine supplementation, or a combination of the two, on the immune system and inflammatory parameters after exercise in simulated hypoxic conditions at 4500 m.” 3 (4500 meter simulated low oxygen state).

What the subjects underwent and experienced:

Nine men underwent three sessions of exercise at 70% VO2 peak until exhaustion as follows:

1) hypoxia with a placebo;

2) hypoxia with 8% maltodextrin (200 mL/20 min) during exercise and for 2 h after;

3) hypoxia after 6 d of glutamine supplementation (20 g/d) and supplementation with 8% maltodextrin (200 mL/20 min) during exercise and for 2 h after.


Research Findings Relative to Glutamine:

Glutamine increased in the hypoxia + carbohydrate + glutamine group after exercise compared with baseline. Carbohydrate or glutamine supplementation shifts the T helper (Th)1/Th2 balance toward Th1 responses after exercise at a simulated altitude of 4500 m. 3

Glutamine Supplementation Supports Weight Loss

The Centers for Disease Control and Prevention (CDC) report that a full 69 percent of adults age 20 years+ are overweight or overtly obese. Researchers reported in September 2014 that glutamine supplementation promotes weight loss in overweight and obese women. Don’t get lost on the fact that women were the target of this study. Clinically I see glutamine is an equal opportunity helper. So here is what the study had to report:

In this pilot study, researchers randomly divided six overweight or obese women to receive a half gram per kilogram body weight per day of glutamine or an isonitrogenous protein supplement for four weeks. Next, the subjects had two weeks without any supplementation as a “wash-out” period, followed by an additional four weeks with the opposite supplement as the initial trial period….The women did not modify diet or lifestyle during the supplementation periods.

After glutamine supplementation, there was a significant reduction in body weight and waist circumference….This pilot study shows that glutamine is safe and effective in favoring weight loss and possibly enhancing glucose metabolism. 4

Dosing:

Individualizing your dosing is always important. Supplementation levels can range from a low of 500 mg to upwards of 15,000 mg (15 grams). When using higher dosing regimens, 3 or 4 divided dosages daily is routinely recommended. With a high dosing regimen, working with a skilled healthcare provider to help you optimize health goals should definitely be a targeted goal when optimizing your body performance goals. Glutamine does not contain gluten and it is different than MSG (monosodium glutamate) or glutamate. Don’t mix glutamine with warm water; tepid or cold water is the way to go.

A potential extra edge, though not necessary, is adding your glutamine to an electrolyte drink. Water transport from the gut into the circulation is known to be promoted by the presence in drinks of glucose and sodium. Glutamine is transported into gut cells by both sodium-dependent and sodium-independent mechanisms, leading to the research suggesting the benefits of electrolyte drinks increasing the rate of fluid absorption above that of ingested water alone. 5,6

There are some important considerations when taking any supplement—input demands output. So staying hydrated and ensuring you have a healthy liver and kidneys are important. After all, the goal is to build your health with positive dietary, lifestyle, and supplemental considerations.

1. Wischmeyer PE. Clinical applications of L-glutamine: Past, present, and future. Nutr Clin Prac. 2003;18(5):377-385.

2. Bowtell JL, Gelly K, Jackman ML, Patel A, Simeoni M, Rennie MJ. Effect of oral glutamine on whole body carbohydrate storage during recovery from exhaustive exercise.J Appl Physiol.1999;86:1770-7.

3.Caris AV et al.Carbohydrate and glutamine supplementation modulates the Th1/Th2 balance after exercise performed at a simulated altitude of 4500 m. Nutrition. 2014 Nov-Dec;30(11-12):1331-6.

4. Laviano A, et al. Eur J Clin Nutr. 2014 Sep 17.

5. Jeukendrup AE, Gleeson M. Sports nutrition: an introduction to energy production and performance. Champaign (IL): Human Kinetics; 2004.

6. Silva AC et al. Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. J Pediatr Gastroenterol Nutr. 1998;26:513–9.

Additional References (Source: Glutamine | University of Maryland Medical Center )

  • Abcouwer SF. The effects of glutamine on immune cells [editorial]. Nutrition. 2000;16(1):67-69.
  • Agostini F, Giolo G. Effect of physical activity on glutamine metabolism. Curr Opin Clin Nutr Metab Care. 2010; 13(1):58-64.
  • Avenell A. Symposium 4: Hot topics in parenteral nutrition Current evidence and ongoing trials on the use of glutamine in critically-ill patients and patients undergoing surgery. Proc Nutr Soc. 2009 Jun 3:1-8. [Epub ahead of print]
  • Buchman AL. Glutamine: commercially essential or conditionally essential? A critical appraisal of the human data. Am J Clin Nutr. 2001;74(1):25-32.
  • Clark RH, Feleke G, Din M, et al. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy-beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind placebo-controlled study. JPEN: J Parenter Enteral Nutr. 2000;24(3):133-139.
  • Field CJ, Johnson IR, Schley PD. Nutrients and their role in host resistance to infection. J Leukoc Biol. 2002 Jan;71(1):16-32.
  • Furukawa S. Saito H, Inoue T, et al. Supplemental glutamine augments phagocytosis and reactive oxygen intermediate production by neutrophils and monocytes from postoperative patients in vitro. Nutrition. 2000;1695):323-329.
  • Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr. 2001 Sep;131(9 Suppl):2556S-61S. [Review].
  • Rakel D. Integrative Medicine, 2nd ed. Philadelphia, PA: Saunders, An Imprint of Elsevier; 2007.
  • Reeds PJ, Burrin DG. Glutamine and the bowel. J Nutr. 2001;131(9 Suppl):2505S-8S.
  • Wilmore DW. The effect of glutamine supplementation in patients following elective surgery and accidental injury. [Review]. J Nutr. 2001;131(9 Suppl):2543S-9S; discussion 2550S-1S.